11/10/2022 0 Comments Proteus mirabilis in dogs![]() Labeler - Taro Pharmaceuticals U.S.A., Inc. Polyethylene glycol 3350 (UNII: G2M7P15E5P) Polyethylene glycol 400 (UNII: B697894SGQ) Mupirocin (UNII: D0GX863OA5) (Mupirocin - UNII:D0GX863OA5) faecium), group Viridans Streptococci, Streptococcus pneumoniae, Corynebacterium hofmanii, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii, Hemophilus influenzae (including β-lactamase-producing strains), Neisseria gonorrheae (including β-lactamase-producing strains), Neisseria meningitidis, Branhamella catarrhalis and Pasteurella multocida, and the anaerobic isolates of Peptostreptococcus anaerobius, Clostridium difficile, and Clostridium sporogenes.Ĭlinical significance of the in vitro data is unknown except for susceptible strains of Staphylcoccus aureus and Staphylococcus intermedius. agalactiae), group D Streptococci (including S. pyogenes), other β Streptococci (including S. Mupirocin is an antimicrobial agent that inhibits the growth of gram-positive and gram-negative bacteria.īacteria susceptible to the action of mupirocin in vitro include the aerobic isolates of Staphylococcus aureus (including methicillin-resistant strains and β-lactamase-producing strains), Staphylococcus intermedius, Staphylococcus epidermidis, other coagulase positive or negative Staphylococci, α-hemolytic Streptococci, β group A Streptococci (including S. Due to this mode of action, mupirocin shows no cross resistance with chloramphenicol, erythromycin, gentamicin, lincomycin, neomycin, novobiocin, penicillin, streptomycin, and tetracycline. Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase. “If you do have a companion animal and you’re prone to these infections,” he said, “be very strict with your hand hygiene before you eat.Mupirocin is a chemical entity produced by fermentation of the organism Pseudomonas fluorescens. Schmidt also cautioned that people who are particularly vulnerable to urinary infections, such as pregnant women, take extra care around their pets, especially when cleaning up after them. “We need to have a common public health approach,” she said. Whether humans are giving resistant organisms to their animals or vice versa, the findings emphasize that the battle against resistance needs a global strategy that involves veterinarians along with human doctors and patients, Marques said. Carbapenem, which the researchers in Portugal did not test for, is also considered a drug of last resort for urinary infections. mirabilis are the two biggest causes of urinary tract infections. In 2013, German researchers writing in the Journal of Antimicrobial Therapy described finding carbapenem-resistant Escherichia coli and Klebsiella urinary infections in six dogs - a discovery later called a phenomenon “of great concern” in a commentary in the same journal. While the new research is broader, it isn’t the first study to raise concerns about the role of companion animals in difficult-to-treat urinary infections. It’s not clear how the patient contracted the resistance, but given colistin’s role as a last-ditch drug, it raised the specter of an unstoppable microbe. In May, scientists reported the discovery of a woman with a urinary infection resistant to colistin, a rarely used drug of last resort ( SN Online: 5/27/16). In humans, doctors have watched warily as resistance to urinary tract infections has grown. ![]() In a third study, which tested for resistance in urinary tract infections in pets across Europe, patterns of drug resistance in dogs and cats tracked that of humans, the researchers found. ![]() Other research found worrisome multidrug resistance in infections caused by Klebsiella. An example: Resistance to a class of drugs known as third-generation cephalosporins grew from 2 percent of samples in 2004 to 20 percent today. In one study, samples of the bacterium Proteus mirabilis taken over 16 years in Portugal showed a steady climb in the prevalence of resistant strains. The new research found a growing resistance in veterinary infections to antibiotics critical for treating human illness. Other research has examined human-pet sharing of bacteria, but the subject has been little explored for urinary tract infections, which are extremely common. ![]() Either way, scientists worry that companion animals provide another haven for bacteria to mingle and pick up genes that give them resistance to drugs, said Michael Schmidt of the Medical University of South Carolina in Charleston, who was not involved in the new work. ![]()
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